Miu Miu logo plaque cardholder Discount 100 Authentic Cheap Wholesale Discount Looking For Zb8iMIVV

SKU75419069920600
Miu Miu logo plaque cardholder Discount 100% Authentic Cheap Wholesale Discount Looking For Zb8iMIVV
Miu Miu logo plaque cardholder
Les cookies Google Analytics
Ce site utilise des cookies de Google Analytics, ces cookies nous aident à identifier le contenu qui vous interesse le plus ainsi qu'à repérer certains dysfonctionnements. Vos données de navigations sur ce site sont envoyées à Google Inc

Teaching Controversy Mapping Go back to the projects...

Controversy mapping

The economic inequities, the environmental crises, the bioethical conundrums and all the issues troubling modern societies are imbroglios of politics, ethics and technologies impossible to disentangle. In these hybrid situations, public participation becomes more and more difficult. To navigate a world of uncertainties, future citizens need to be equipped with tools to explore and visualize the complexity of public debate . The purpose of mapping controversy is to contribute to the development of these tools through the creative use of digital technologies.

For a few examples of the works realized by the students of the controversy mapping course, see: the archive of the controversy websites ( http://controverses.sciences-po.fr/archiveindex/ ).

Introduced by Bruno Latour more than fifteen years ago, the cartography of controversies is currently taught in several European and American universities (Paris, Copenhagen, Milan, Manchester, Amsterdam, Liège, Lausanne, Dublin, Oslo, Padova, Trento, Cambridge, Mass., São Paulo, Rio de Janeiro, Buenos Aires…).

Characterized by a radically experimental approach , controversy mapping is developed through several research projects – MACOSPOL (mapping controversies on science for politics) 2007-09 – MEDEA (mapping environmental debate on adaptation) 2011-14 – EMAPS (electronic maps to assist public science) 2011-14 – FORCCAST (formation à la cartographie des controverses pour l’analyse de sciences et des techniques) 2012-20 Cheap Sale Enjoy Stella McCartney fringed stars boyfriend jeans Buy Cheap Fashionable 6CPYPwe7iy

The course team

Tommaso Venturini (responsible of the course) tommaso.venturini@sciences-po.fr / 01 45 49 53 71 / médialab, Sciences Po, 13, rue de l’Université Mathieu Jacomy (teaching assistant) / mathieu.jacomy@sciences-po.org Thomas Tari (teaching assistant) / thomas.tari@univ-paris-est.fr Axel Meunier (teaching assistant) / axel.meunier@sciences-po.fr Nicolas Baya-Laffite (teaching assistant) / nicolas.bayalaffite@sciences-po.fr

The course in a nutshell

Understand the junction between science and society, observe it through the case study of a specific controversy and make the results of this analysis public.

Benefits for the students

Aims of the course

The most important task of the course is the analysis of a socio-technical controversy . Achieving this task implies understanding some crucial notions of STS (Science and Technology Studies) and mastering a number of traditional and digital investigation techniques. The course is meant to teach all that is necessary to accomplish this task.

Course schedule

The course alternates master lectures and practical workshops. – The master lectures are meant to introduce and discuss the theoretical notions and the methodological tools necessary for controversy mapping. – The practical workshops (in smaller groups) are meant to assure a constant and personalized support until the final exam and to provide a space for sharing and confrontation among the students.

Course organization

groups of 6 students

Primary Ciliary Dyskinesia (PCD, Nº21 embellished crossbody bag High Quality Online Offer Visit New Online Sale Low Shipping Q7LaC
) or Immotile Cilia Syndrome (ICS) is an hereditary condition affecting the motility of ciliary and spermatozoa flagella. The disorder, transmitted in an autosomal recessive mode, has an incidence of 16,000-30,000. Dysmotility to complete immotility of cilia and flagella results in multisystemic disease of varying severity, characterized by infections of the upper respiratory tract, bronchiectasis, and male sterility. When heterotaxia (situs inversus) is associated, as in in up to half of patients, PCD is also referred to as Kartagener syndrome ( Discount Really Harmony Paris striped zipped sweatshirt Sale Many Kinds Of 2018 Discount 0pM3QnB19L
). The condition is most often associated with ultrastructural defects of axoneme, the skeleton of cilia and flagella, which is constituted of several families of proteins including dyneins, kinesin and microtubule-associated proteins (MAPs).

Our recent genome-wide linkage studies in over 30 families identified several chromosomal regions which may anchor genes linked to the phenotype, suggesting that the disease is genetically highly heterogeneous1. These results, were compatible with the localization of several dynein genes, long standing candidates for PCD since roughly half of the structural defects are in the dynein arm. Indeed, in the last few months, we and others have found mutations in 3 distinct axonemal dynein genes (DNAI1, DNAH11, DNAH5) in Kartagener syndrome. Since each of these mutations was observed in only few families thusfar, other genes, probably including additional isoforms of dynein, must also be responsible for PCD. Multiple dynein proteins are encoded by a family of distinct genes mapping to different chromosomes.

( Dodo Bar Or floral print tiered ruffle dress Amazon Cheap Online hTJX1
)

Balenciaga Red Everyday Medium Leather tote bag Sale How Much qeT8c

Periodical Bulletin on the scientific research on Primary Ciliary Dyskinesia at Medical Genetics

Study of the genetic etiology of Primary Ciliary Dyskinesia : A summary of progress in the identification of disease-causing genes, November 2001. This bulletin was sent to physicians who collaborated to our research project on PCD. This document provide informations also that physicians are encouraged to forward to the patients and families who where included in the study.

A MSGM striped print hoodie Free Shipping Footlocker Finishline WWoP5eP
on Kartagener Syndrome Project by the group.

A gene that contributes to heart laterality and is responsible for some cases of Kartagener syndrome, MRZ striped asymmetric Tshirt Official Sale Online Browse For Cheap Original For Sale Discount Outlet rF8GNiR
of the University of Geneva Medical School and collaborators.

DGM Home page | DGM Contacts

Table 2. Overlap of FCHL modules with FCHL differentially expressed gene list.

Free Shipping 2018 New Givenchy small Antigona tote Outlet Professional Clearance Exclusive bJ4ljtJsC

Integrating the co-expression modules with genetic data provides insight into the function and regulation of each module. The turquoise and tan MEs were associated with the rs3737787 genotypes (turquoise ME correlation = 0.28, p-value = 0.02; tan ME correlation = 0.33, p-value = 0.006) ( Alinka Marina diamond stud earrings Discount Huge Surprise Sale Shop Best Store To Get Cheap Online With Mastercard For Sale ssYquRNFEM
). We observed a significant overlap between the rs3737787 correlated genes and both the turquoise and tan module genes ( Outlet Discounts Outlet Pre Order Vivetta striped boxy shirt Free Shipping Visa Payment Cheap Official Clearance Professional quAXcl33jp
). The tan module was the only module to be associated with FCHL, the FCHL component trait signature, and rs3737787 genotypes. To emphasize the biological implications of the tan module, we renamed it as the USF1 -regulated FCHL-associated (URFA) module. The turquoise module was not significantly associated with FCHL, suggesting that while the expression of turquoise module genes depends on rs3737787 genotypes, the gene functions of the turquoise module are less likely to be related to FCHL ( Valextra Pochette shoulder bag Outlet Perfect Buy Cheap Sneakernews 2hN3ops8
, Proenza Schouler wrap pleat buckled trousers Amazing Price Sale Online OvnCm
). These results demonstrate that rs3737787 genotypes predict the expression of many genes, some of which predispose to FCHL.

Table 3. Overlap of rs3737787 modules with genes differentially expressed by the rs3737787 genotypes.

https://doi.org/10.1371/journal.pgen.1000642.t003

We should point out that our sample size of 70 individuals provides 80% power to detect a significant association (p-value≤0.05) with correlation coefficient = 0.33, and only limited power to rule out associations with a correlation coefficient<0.33. To have 80% power to detect a significant association (p-value≤0.05) when the true correlation coefficient = 0.2 requires 194 individuals, and when the true correlation coefficient = 0.1 requires 783 individuals. Therefore our sample size does not permit us to rule out associations of smaller magnitude (correlation coefficient<0.33). However, our sample size of 70 individuals provides enough power to detect significant moderate correlations (correlation coefficient≥0.33) between eigengenes, SNPs, and clinical traits.

The URFA module contains 504 co-expressed genes that are enriched for the gene ontology (GO) Biological Process categories of Cellular Lipid Metabolic Processes and Lipid Metabolic Processes (p-values = 1.0×10 −5 and 9.3×10 −6 ; Benjamini-Hochberg multiple comparison corrected p-values = 0.022 and 0.039) ( Lesca round shaped glasses Online Store Om3QxUPN
). The URFA ME accounts for 10% of the variation of FCHL, 6% of TC, 17% of TG, and 9% of ApoB ( Officine Generale henley blouse Really Outlet Best Place xnUCv
). The fact that the URFA ME was associated with rs3737787 reflects the fact that most module genes are at least partially regulated by this SNP. To evaluate whether the module causally affects FCHL component traits, we utilized the Network Edge Orienting (NEO) R software package [37] which takes SNP genotypes as input into structural equation models that compute causal edge orienting scores (referred to as LEO.NB scores). Since we are only considering a single SNP (rs3737787) we computed LEO.NB. SingleMarker scores for the causal orientation of a ME→trait. The LEO.NB. SingleMarker score is a relative model fitting index for the causal model (rs3737787→ME→trait) relative to alternative causal models, and the larger the value for the LEO.NB. SingleMarker score the stronger the evidence that this causal orientation is correct. We required that the our causal model fit at least two times better than the next best alternative model, which equates to a LEO.NB. SingleMarker score of 0.3 Tommy Hilfiger hooded zipped jacket Discount 100% Guaranteed bjHLU1
(please see the Diesel distressed patch denim shorts Exclusive Sale Online Free Shipping Sast Clearance Best Buy Cheap Store Clearance Cheap Price oZJNZx9T0j
for a detailed description). We found sufficient evidence to infer a causal relationship between the URFA ME and fasting plasma TGs levels (LEO.NB. SingleMarker score = 0.31), the key component trait of FCHL. The LEO.NB. SingleMarker score for the URFA ME to FCHL was 0.25. We then used the NEO software to prioritize genes inside the URFA module by calculating the LEO.NB. SingleMarker scores evaluating the causal model (rs3737787→gene expression→trait). We identified 18 causal candidate genes for FCHL, and 171 causal candidate genes for fasting plasma TGs levels ( Table S7 ). We observed 13 causal candidate genes for both FCHL and TG. None of the URFA module genes showed evidence for causally affecting TC or ApoB. Since our interest was in FCHL disease status, we characterized the 18 causal candidate genes for FCHL disease status as potential candidate genes for genetic association studies in Mexican FCHL families ( Table 4 ).

We inspire people to plant, nurture and celebrate trees.

The Arbor Day Foundation is a 501(c)(3) nonprofit conservation and education organization. A million members, donors, and partners support our programs to make our world greener and healthier.

Multi Coloured Lanvin Le Petit Sac box clutch Cheap Wide Range Of Free Shipping Shop Buy Cheap Cost TJA8KZf

Info
Action
Connect
Related Sites
© 2018 Arbor Day Foundation. Privacy policy